Hydrochloric Acid → HCID 178515792, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-{2-[(1H-indazol-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-carbonyl}piperazine-1-carboxylate (0.054 g, 0.11 mmol) in methylene chloride (3.0 mL) was added with a 4 M solution of hydrogen chloride in 1,4-dioxane (3.0 mL), and then the mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was azeotroped twice with toluene under reduced pressure. The residual solid was added with water, and then the mixture was adjusted to pH 9 with saturated aqueous sodium hydrogencarbonate, and the solid was collected by filtration and dried to obtain (Z)-2-[(1H-indazol-3-yl)methylene]-6-hydroxy-7-(piperazine-1-carbonyl)benzofuran-3(2H)-one (0.018 g, 42%).

Provenance & Evidence