Water → HCID 71278662, compound

Participants

Reaction Steps

A solution of 6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-carboxylic acid (0.30 g, 1.6 mmol) in DMF (10 mL) was added with potassium carbonate (0.63 g, 4.6 mmol) and dimethyl sulfate (0.48 g, 3.8 mmol), and the mixture was stirred at room temperature for 1 hour, and at 40° C. for 3 hours. The reaction mixture was added with water, the mixture was extracted with ethyl acetate, and then the organic layer was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain methyl 6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-carboxylate (0.25 g, 71%).

Provenance & Evidence