Hydrochloric Acid → HCID 178487268, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-carboxylate (0.070 g, 0.20 mmol) was added with methanol (3.0 mL), dimethyl sulfoxide (1.0 mL), and water (0.50 mL), and then added with lithium hydroxide monohydrate (0.025 g, 0.60 mmol), and the mixture was stirred at 30° C. for 10 hours. The reaction mixture was made acidic with 3 N hydrochloric acid, and the solid formed was collected by filtration. The solid was suspended in chloroform/methanol (95:5), then collected by filtration and dried to obtain (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-carboxylic acid (0.045 g, 67%).

Provenance & Evidence