Formaldehyde → HCID 71278800, compound

Participants

Reaction Steps

A solution of 6-hydroxybenzofuran-3(2H)-one (0.600 g, 4.00 mmol) in ethanol (4 mL) was added with 1-(methylsulfonyl)piperazine (0.657 g, 4.00 mmol), and 37% aqueous formaldehyde (0.325 g, 4.00 mmol) at room temperature. The reaction mixture was stirred overnight at room temperature, and then concentrated. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain 6-hydroxy-7-{[4-(methylsulfonyl)piperazin-1-yl]methyl}benzofuran-3(2H)-one (0.169 g, 12%).

Provenance & Evidence