Piperidine → (2Z)-6-hydroxy-2-(2H-indazol-3-ylmethylidene)-7-[(4-methylsulfonylpiperazin-1-yl)methyl]-1-benzofuran-3-one

Participants

Reaction Conditions

Reaction Steps

A solution of 6-hydroxy-7-{[4-(methylsulfonyl)piperazin-1-yl]methyl}benzofuran-3(2H)-one (0.0681 g, 0.209 mmol) in methanol (0.8 mL) was added with 1H-indazole-3-carboxaldehyde (0.0305 g, 0.209 mmol) and piperidine (0.00178 g, 0.0209 mmol), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was cooled to room temperature, and then added with methanol (2 mL), and the precipitated solid was suspended in methanol and thereby washed to obtain (Z)-2-[(1H-indazol-3-yl)methylene]-6-hydroxy-7-{[4-(methylsulfonyl)piperazin-1-yl]methyl}benzofuran-3(2H)-one (0.0503 g, 53%).

Provenance & Evidence