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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1749931Generated: October 31, 2026

5-(Methanesulfonyl)-2,3-dihydro-1H-indole → 5-(Methylsulfonyl)-1H-indole

https://huagongshe.com/reaction/1749931

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methanesulfonyl)-2,3-dihydro-1H-indoleHCID 2736136—
CatalystHCID 178418406HCID 178418406—
SolventChloroformHCID 6212—
Product5-(Methylsulfonyl)-1H-indoleHCID 1497323071.6%

Reaction Steps

A solution of 5-(methylsulfonyl)indoline (0.213 g, 1.08 mmol) in chloroform (4 mL) was added with manganese dioxide (0.939 g, 10.8 mmol), and the mixture was stirred at room temperature for 9 hours. The reaction mixture was filtered through Celite, and the resulting filtrate was concentrated to obtain 5-(methylsulfonyl)-1H-indole (0.151 g, 71%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09156827B2
Source datasetuspto-grants-2015_10
ORD IDord-1b8962c90d08464d995d6db8721b1993
Source noteuspto-grants-2015_10