反应详情

A solution of tert-butyl 4-[3-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)prop-2-ynyl]piperazine-1-carboxylate (0.0748 g, 0.194 mmol) obtained in Example B46, Step 4 in ethanol (5 mL) was added with 5% palladium/carbon (wetted with 50% water, 0.0700 g), and the mixture was stirred at room temperature for 2 hours under a hydrogen atmosphere. The reaction mixture was filtered through Celite, the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl 4-[3-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)propyl]piperazine-1-carboxylate (0.0642 g, 85%).

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated
3. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)