Piperidine → HCID 178487159, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-[4-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate (0.113 g, 0.273 mmol) in methanol (1 mL) was added with 1H-indazole-3-carboxaldehyde (0.0399 g, 0.273 mmol) and piperidine (0.0186 g, 0.218 mmol), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl (Z)-4-(4-{2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}-2-methylbut-3-yn-2-yl)piperazine-1-carboxylate (0.136 g, 91%).

Provenance & Evidence