Trifluoroacetic acid → HCID 178487158, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-(4-{2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}-2-methylbut-3-yn-2-yl)piperazine-1-carboxylate (0.122 g, 0.225 mmol) in methylene chloride (4 mL) was added with trifluoroacetic acid (4 mL), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated, and then the residue was dissolved in water (10 mL). The solution was added with saturated aqueous sodium hydrogencarbonate (10 mL), and the precipitated solid was collected by filtration. The solid was washed with water, and then dried under reduced pressure to obtain (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-[3-methyl-3-(piperazin-1-yl)but-1-ynyl]benzofuran-3(2H)-one (0.0259 g, 26%).

Provenance & Evidence