Benzoyl Peroxide → HCID 86682096, compound

Participants

Reaction Steps

A solution of 6-methoxy-7-methylbenzofuran-3(2H)-one (0.670 g, 3.76 mmol) in carbon tetrachloride (38 mL) was added with N-bromosuccinimide (0.737 g, 4.14 mmol) and benzoyl peroxide (0.0456 g, 0.188 mmol), and the mixture was refluxed for 4 hours by heating. The reaction mixture was cooled to room temperature, and then filtered, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 7-(bromomethyl)-6-methoxybenzofuran-3(2H)-one (0.411 g, 42%).

Provenance & Evidence