Hydrazine hydrate (1:1) → HCID 71278717, compound

Participants

Reaction Steps

A solution of hydrazine monohydrate (0.0102 g, 0.203 mmol) in water (1.25 mL) was cooled to 0° C., and added with a solution of 3-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]pentane-2,4-dione (0.0533 g, 0.193 mmol) in acetic acid (2 mL), and the mixture was stirred for 18 hours with warming it to room temperature. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate, thereby made basic, and extracted three times with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 7-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-6-methoxybenzofuran-3(2H)-one (0.0427 g, 81%).

Provenance & Evidence