Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750030Generated: October 25, 2026

tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate → N-(2-(pyrrolidin-3-ylmethoxy)phenyl)pyridine-2-sulfonamide trifluoroacetate

https://huagongshe.com/reaction/1750030

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 5237175—
ReactantN-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetateHCID 67607774—
ProductN-(2-(pyrrolidin-3-ylmethoxy)phenyl)pyridine-2-sulfonamide trifluoroacetateHCID 6760989439%

Reaction Steps

Intermediate 6b (solid) is prepared using tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate instead of tert-butyl 4-hydroxypiperidine-1-carboxylate using the procedure described for 6a (yield: 39% over the 4 steps).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09156834B2
Source datasetuspto-grants-2015_10
ORD IDord-449a276c7ab64bd7b1c4667f346d9ae5
Source noteuspto-grants-2015_10