HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67609737, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 6-Chloro-2-piperazin-1-yl-1,3-benzoxazole | HCID 25219078 | — |
| Reactant | 3-(Pyridine-2-sulfonamido)benzoic acid | HCID 67609300 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67609737 | HCID 67609737 | 68% |
Reaction Steps
Compound 10 is prepared using synthesis method 2: intermediate 3b (0.16 g, 0.67 mmol) is placed in 21 mL of acetonitrile in the presence of 0.18 g (0.67 mmol) of intermediate 5a and 103 μL of Et3N. 0.21 g (0.67 mmol) of TBTU is then added and the mixture is then stirred for 5 h at ambient temperature. After evaporation under reduced pressure the residue is taken up by water and extracted using AcOEt. After the organic phases are dried and after reduction to dryness the residue obtained is purified by flash chromatography (CH2Cl2-MeOH, gradient 99-1 to 95-5 over 65 min). 0.23 g of solid is obtained (yield: 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156834B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-3be7183c172245989163d54d7c19a275 |
| Source note | uspto-grants-2015_10 |