2,5-Dichlorobenzooxazole → N-(2-(1-(5-chlorobenzo[d]oxazol-2-yl)piperidin-4-yloxy)phenyl)-pyridine-2-sulfonamide

HRID 1750039Notes

Reaction equation

HRID 1750039 reaction equation
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=2[N:6]=1.FC(F)(F)C(O)=O.[NH:19]1[CH2:24][CH2:23][CH:22]([O:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[NH:32][S:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=2)(=[O:35])=[O:34])[CH2:21][CH2:20]1>>[Cl:11][C:8]1[CH:9]=[CH:10][C:4]2[O:3][C:2]([N:19]3[CH2:24][CH2:23][CH:22]([O:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[NH:32][S:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)(=[O:35])=[O:34])[CH2:21][CH2:20]3)=[N:6][C:5]=2[CH:7]=1

Participants

3

Reactant 2

HCID 103975782,5-DichlorobenzooxazoleHCID 67607774N-(2-(piperidin-4-yloxy)phenyl)pyridine-2-sulfonamide trifluoroacetate

Product 1

HCID 67608352N-(2-(1-(5-chlorobenzo[d]oxazol-2-yl)piperidin-4-yloxy)phenyl)-pyridine-2-sulfonamide

Procedure

Compound 24 is prepared using synthesis method 3 using intermediates 2h and 6a (yield: 92%).

Sources & evidence

ORD record
ord-582b269d80684a1bb112bbd28d31136a
Source dataset
uspto-grants-2015_10
Patent number
US09156834B2

Reaction notes

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