反应详情

1.43 g of N-bromosuccinimide was added to a mixture of 1.52 g of methyl-(5-trifluoromethylsulfanylpyridin-2-yl)-amine and 24 ml of chloroform, and the mixture was stirred at room temperature for 1 hour. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The combined organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 1.96 g of (3-bromo-5-trifluoromethylsulfanylpyridin-2-yl)-methylamine.

1. extractionthe mixture was extracted with chloroform
2. dry with materialThe combined organic layer was dried over anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure