HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → HCID 66634166, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-hydroxy-1H-indazole | HCID 135483987 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 66634166 | HCID 66634166 | 7.3% |
Reaction Steps
A mixture of 1H-indazol-6-ol (600 mg, 4.5 mmol), 1,3-dibromopropane (1.4 mL, 13.4 mmol) and anhydrous K2CO3 (618 mg, 4.5 mmol) in EtOH (20 mL) was heated to reflux and stirred overnight. Filtration gave a yellow solid which was purified by column chromatography (elution with PE/EtOAc=3:1) to afford 6-(3-bromopropoxy)-1H-indazole (intermediate 44) (84 mg, 7%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156822B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-df0c33c417ee407590e3a48f24c2c4cb |
| Source note | uspto-grants-2015_10 |