Hydrochloric Acid → HCID 86714379, compound

Participants

Reaction Steps

80 mg of (S)-2-[4-(1-Isopropyl-2-methyl-propylamino)-3-(2-thiophen-2-yl-acetyl-amino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester and 2 ml of hydrochloric acid (4M in dioxin) were heated in a microwave reactor for 2 min to 100° C. and for 15 min to 130° C. The reaction was then concentrated in vacuo and the resulting residue purified by HPLC to obtain 3 mg (4%) of (S)-2-{[1-(1-Isopropyl-2-methyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carbonyl]-amino}-4-methyl-pentanoic acid.

Provenance & Evidence