HCID 86714407, compound → HCID 86714378, compound

Participants

Reaction Steps

1.35 g of (S)-2-[4-(1-Isopropyl-2-methyl-propylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester were dissolved in 14 ml ethanol, 0.30 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 4 h. The catalyst was removed by filtration over celite, and the reaction mixture was concentrated to yield 1.00 g (79%) of (S)-2-[3-Amino-4-(1-isopropyl-2-methyl-propylamino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester as a viscous oil, which was used without further purification.

Provenance & Evidence