Hydrochloric Acid → Cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2.93 g of 3-(2-Cyclopentyl-acetylamino)-4-(1-ethyl-propylamino)-benzoic acid methyl ester were dissolved in 7.5 ml of dry dioxane and 7.5 ml of 4M hydrochloric acid in dioxane were added. The reaction was heated in a microwave reactor to 140° C. for 30 min. The reaction mixture was concentrated, the residue was taken up in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, dried over magnesium sulphate and concentrated to yield 26.9 g (97%) of 2-Cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester as a brown solid which was used in the next step without further purification.

Herkunft & Nachweise