反应详情

温度

140 °C

To 3.22 g of -Cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester 5 ml of methanol and 7 ml of 2 M aqueous sodium hydroxide solution were added and the reaction was heated in a microwave reactor to 140° C. for 1 h. The methanol was removed by distillation and the mixture was adjusted to pH 5 by the addition of 2M aqueous hydrochloric acid. The precipitated product was collected by filtration, washed with water and dried in vacuo. 2.22 g (65%) of Cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid were obtained as light-brown solid.

1. customThe methanol was removed by distillation
2. additionthe mixture was adjusted to pH 5 by the addition of 2M aqueous hydrochloric acid
3. filtrationThe precipitated product was collected by filtration
4. washwashed with water
5. customdried in vacuo