Hydrochloric Acid → 1-(1-Ethyl-propyl)-2-isoxazol-5-ylmethyl-1H-benzoimidazole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To 1.06 g 4-(1-Ethyl-propylamino)-3-(2-isoxazol-5-yl-acetylamino)-benzoic acid methyl ester were added 7.5 ml of 4M hydrochloric acid in dioxane. The reaction mixture was heated to 130° C. for 20 min in a microwave reactor. After cooling to rt 2 ml of water were added and the reaction was again heated to 130° C. for 20 min. The reaction was concentrated and the residue purified by chromatography (silica, ethyl acetate/heptane) to yield 0.85 g (90%) of 1-(1-Ethyl-propyl)-2-isoxazol-5-ylmethyl-1H-benzoimidazole-5-carboxylic acid.

Provenance & Evidence