Hydrochloric Acid → HCID 86714428, compound

Participants

Reaction Steps

20.0 g 4-(Cyclohexylmethyl-amino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester were dissolved in 65 ml dioxane and reacted with 33 ml of 4M hydrochloric acid in dioxane at rt for 4 h. The reaction was concentrated and the residue purified by chromatography (silica, ethyl acetate/heptane) to yield 13.6 g (71%) of 1-Cyclohexylmethyl-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid methyl ester.

Provenance & Evidence