Water → HCID 86714430, compound

Participants

Reaction Steps

140 mg of (S)-2-[4-(2-Chloro-phenylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester were dissolved in 5 ml ethyl acetate, 342 mg of tin(II)chloride-dihydrate were added and the mixture was stirred at rt for 4 h. Water was added to the reaction. The mixture was filtrated over celite. The pH of the filtrate was adjusted to 7, the layers were separated and the organic layer was extracted with ethyl acetate twice. The combined organic layers were dried over sodium sulphate and concentrated to yield 103 mg (79%) of (S)-2-[3-Amino-4-(2-chloro-phenylamino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester.

Provenance & Evidence