HCID 86714433, compound → HCID 86714432, compound

Participants

Reaction Steps

50 mg of (S)-2-[4-(1,3-Dimethyl-butylamino)-3-nitro-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester were dissolved in 0.5 ml, ethanol, 5 mg of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 4 h. The catalyst was removed by filtration over celite, and the reaction mixture was concentrated to yield 45 mg (99%) of (S)-2-[3-Amino-4-(1,3-dimethyl-butylamino)-benzoylamino]-4-methyl-pentanoic acid tert-butyl ester, which was used without further purification.

Provenance & Evidence