反应详情

9.27 g 4-((1R,2R)-2-Methyl-cyclohexylamino)-3-nitro-benzoic acid methyl ester were dissolved in 100 ml ethanol, 0.20 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 3 h. The catalyst was removed by filtration over celite, the filtrate was concentrated to obtain 8.20 g (99%) of 3-Amino-4-((1R,2R)-2-methyl-cyclohexylamino)-benzoic acid methyl ester. C15H22N2O2 (262.35), LCMS (method 8—1—1): Rt=0.77 min, m/z=263.15 [M+H]+

1. customThe catalyst was removed by filtration over celite
2. concentrationthe filtrate was concentrated