Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750236Generated: October 31, 2026

2-Methylcyclohexylamine hydrochloride, (1S,2S)- → 1-((1S,2S)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid

https://huagongshe.com/reaction/1750236

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylcyclohexylamine hydrochloride, (1S,2S)-HCID 12714252—
Reactant1-((1R,2R)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acidHCID 86714436—
Reactant3-Amino-4-((1S,2S)-2-methyl-cyclohexylamino)-benzoic acid methyl esterHCID 86714444—
Product1-((1S,2S)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acidHCID 86714443—

Reaction Steps

1-((1S,2S)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid was prepared in analogy to the synthesis of 1-((1R,2R)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid via 3-Amino-4-((1S,2S)-2-methyl-cyclohexylamino)-benzoic acid methyl ester and starting from (1S,2S)-2-Methyl-cyclohexylamine-hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09156796B2
Source datasetuspto-grants-2015_10
ORD IDord-35e0531eede94801bf04a3d3d0b7656a
Source noteuspto-grants-2015_10