反应详情

12.74 g 4-(2-Methyl-cyclopentylamino)-3-nitro-benzoic acid methyl ester were dissolved in 80 ml methanol, 0.39 g of palladium on carbon (10%) were added and the mixture was hydrogenated at 5 bar for 16 h. The catalyst was removed by filtration over celite, the filtrate was concentrated and the residue purified by chromatography (silica, ethyl acetate/hexane) to obtain 8.17 g (72%) of 3-Amino-4-(2-methyl-cyclopentylamino)-benzoic acid methyl ester.

1. customThe catalyst was removed by filtration over celite
2. concentrationthe filtrate was concentrated
3. customthe residue purified by chromatography (silica, ethyl acetate/hexane)