Thionyl Chloride → 2-iodofuran-3-carbonyl Chloride

Participants

Reaction Conditions

Reaction Steps

To 2-iodofuran-3-carboxylic acid (6.21 g, 26.1 mmol) was added thionyl chloride (20 ml, 274 mmol). The solution was heated while stirring to 70° C. for 5 h. The mixture was reduced in vacuo and the residue azeotroped with toluene (2×30 ml) to afford the crude title compound (6.69 g, 100%), which was used in the next step without further purification.

Provenance & Evidence