Sodium Hydroxide → 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid

Beteiligte Stoffe

Reaktionsschritte

A solution of the compound (3.96 g, 10.22 mmol) obtained in step 5 and 1N aqueous sodium hydroxide solution (15.33 mL, 15.33 mmol) in ethanol (50 mL) was stirred at room temperature for 2 hr. To the reaction mixture was further added 1N aqueous sodium hydroxide solution (5.0 mL, 5.0 mmol), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. 1N Hydrochloric acid was added thereto, and the precipitate was collected by filtration, and crystallized from ethyl acetate and hexane to give 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (2.52 g, 7.01 mmol, 69%) as a pale-yellow powder.

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