Potassium hydroxy sulfite → HCID 86721194, compound

Participants

Reaction Conditions

Reaction Steps

To a mixed solution of 4-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetyl)thiomorpholine (100 mg, 0.22 mmol) in THF (2 mL), MeOH (2 mL) and water (2 mL) was added Oxone (290 mg, 0.47 mmol) at 0° C., and the mixture was stirred at 0° C. for 3 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine and dried, and the solvent was evaporated under reduced pressure to give the title compound (82 mg, 0.172 mmol, 76%) as a white powder.

Provenance & Evidence