Water → HCID 86721196, compound

Participants

Reaction Steps

A solution of 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (60 mg, 0.17 mmol), HATU (76 mg, 0.20 mmol), DEIA (0.035 mL, 0.20 mmol) and (tetrahydro-2H-pyran-4-yl)methanamine (0.023 mL, 0.20 mmol) in DMF (1 mL) was stirred at room temperature for 1 day. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 20→100% ethyl acetate/hexane0→5% methanol/ethyl acetate) to give the title compound (44 mg, 0.100 mmol, 60%) as a white powder.

Provenance & Evidence