Tetrahydrofuran → HCID 86721199, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of lithium aluminum hydride (4.93 mg, 0.13 mmol) in THF (3 mL) was added 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (68 mg, 0.15 mmol) at room temperature, and the mixture was stirred at 80° C. for 2 hr. To the reaction mixture was added 1N aqueous sodium hydroxide solution (2 drops), and the mixture was stirred at room temperature for 1 hr. After extraction with ethyl acetate, washing with saturated brine and drying, the solvent was evaporated under reduced pressure. The residue was purified by NH-silica gel column chromatography (solvent gradient; 3→50% ethyl acetate/hexane) to give the title compound (8 mg, 0.019 mmol, 12.15%) as a pale-yellow oil.

Provenance & Evidence