N-Methylpyridine-4-methylamine → HCID 86721200, compound

Participants

Reaction Steps

A solution of 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (60 mg, 0.17 mmol), HATU (76 mg, 0.20 mmol), DIEA (0.035 mL, 0.20 mmol) and N-methyl-1-(pyridin-4-yl)methanamine (20.39 mg, 0.17 mmol) in DMF (1 mL) was stirred at room temperature for 2 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by NH-silica gel column chromatography (solvent gradient; 5→80% ethyl acetate/hexane) to give the title compound (50 mg, 0.108 mmol, 65%) as a white powder.

Provenance & Evidence