4-(Aminomethyl)benzonitrile hydrochloride → HCID 86721209, compound

HRID 1750370Notes

Reaction equation

HRID 1750370 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23]([OH:25])=O)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:27][CH2:28][C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=1>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23]([NH:34][CH2:33][C:32]3[CH:35]=[CH:36][C:29]([C:28]#[N:27])=[CH:30][CH:31]=3)=[O:25])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 99422504-(Aminomethyl)benzonitrile hydrochlorideHCID 867211822-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid

Product 1

HCID 86721209HCID 86721209, compound

Procedure

Using 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid and p-(aminomethyl)benzonitrile hydrochloride and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-a83f973959774c45a00f389b9be309dd
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

Loading…