3-Hydroxyisovaleric acid → HCID 86721214, compound

HRID 1750373Notes

Reaction equation

HRID 1750373 reaction equation
Cl.[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:4])[CH3:3].[OH:29][C:30]([CH3:36])([CH3:35])[CH2:31][C:32](O)=[O:33]>>[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:24][CH2:25][N:26]([C:32](=[O:33])[CH2:31][C:30]([CH3:36])([OH:29])[CH3:35])[CH2:27][CH2:28]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 693623-Hydroxyisovaleric acidHCID 86721211HCID 86721211, compound

Product 1

HCID 86721214HCID 86721214, compound

Procedure

Using 4-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}piperidine monohydrochloride and 3-hydroxy-3-methylbutyric acid and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-5fcae42b7ec34e0eb3426e1c197f2104
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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