2(2H-Perfluoro-2-propyl)acetic acid → HCID 86721215, compound

HRID 1750374Notes

Reaction equation

HRID 1750374 reaction equation
Cl.[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:4])[CH3:3].[F:29][C:30]([F:41])([F:40])[CH:31]([C:36]([F:39])([F:38])[F:37])[CH2:32][C:33](O)=[O:34]>>[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:24][CH2:25][N:26]([C:33](=[O:34])[CH2:32][CH:31]([C:30]([F:40])([F:41])[F:29])[C:36]([F:37])([F:39])[F:38])[CH2:27][CH2:28]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 27821902(2H-Perfluoro-2-propyl)acetic acidHCID 86721211HCID 86721211, compound

Product 1

HCID 86721215HCID 86721215, compound

Procedure

Using 4-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}piperidine monohydrochloride and 4,4,4-trifluoro-3-(trifluoromethyl)butyric acid and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-e54151afd5004f18b169cfd4556b04de
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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