4-Aminomethyltetrahydropyran → HCID 90184521, compound

HRID 1750376Notes

Reaction equation

[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][C:19]([CH2:22][C:23]([OH:25])=O)=[CH:20][N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[O:26]1[CH2:31][CH2:30][CH:29]([CH2:32][NH2:33])[CH2:28][CH2:27]1>>[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][C:19]([CH2:22][C:23]([NH:33][CH2:32][CH:29]3[CH2:30][CH2:31][O:26][CH2:27][CH2:28]3)=[O:25])=[CH:20][N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 90184542HCID 90184542, compound

Product 1

HCID 90184521HCID 90184521, compound

Procedure

Using the compound obtained in step 2 and (tetrahydro-2H-pyran-4-yl)methanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-1ab6785b78b74e669671c3e59d1d64f0
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156837B2

Reaction notes

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