Sodium Hydroxide → HCID 86721218, compound

Participants

Reaction Steps

To a mixed solution of the compound (2.86 g, 9.46 mmol) obtained in step 1 in THF (15 mL) and ethanol (15 mL) was added 1N aqueous sodium hydroxide solution (14.19 mL, 14.19 mmol) at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure, and 1N hydrochloric acid was added thereto. The precipitate was collected by filtration to give 1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid (2.59 g, 9.44 mmol, 100%) as a white powder.

Provenance & Evidence