Ethanol → HCID 86010495, compound

Participants

Reaction Steps

A solution of ethyl 3-(4-fluorophenyl)-3-oxopropanoate (1.50 g, 7.14 mmol) and DMFDMA (1.15 mL, 8.56 mmol) in toluene (23 mL) was heated under reflux for 15 hr. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in ethanol (23 mL). To the ethanol solution was added phenylhydrazine (0.779 mL, 7.85 mmol) at room temperature, and the mixture was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (solvent; 2% ethyl acetate/hexane) to give ethyl 5-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxylate (1.90 g, 86%) as a yellow powder.

Provenance & Evidence