Hydrochloric Acid → HCID 86721225, compound

Participants

Reaction Steps

A solution of the compound (220 mg, 0.540 mmol) obtained in step 5 and 1N aqueous sodium hydroxide solution (1.08 mmol, 1.08 mL) in ethanol (5.0 mL) was heated under reflux for 1 hr. The reaction mixture was cooled to room temperature, and concentrated hydrochloric acid was added until the mixture became pH 6. The mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (solvent; 33% ethyl acetate/hexane) to give {2-[5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetic acid (140 mg, 68%) as a yellow powder.

Provenance & Evidence