Sodium Hydroxide → HCID 86721230, compound

Participants

Reaction Steps

A solution of ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate (245 mg, 0.709 mmol) and 6N aqueous sodium hydroxide solution (0.355 mL, 2.13 mmol) in ethanol (2.8 mL) was heated under reflux for 2 hr. Ethanol was evaporated, and 2N hydrochloric acid was added until the mixture became pH2. The precipitate was collected by filtration to give {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetic acid (235 mg, 100%) as a yellow powder.

Provenance & Evidence