1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 86721232, compound

Participants

Reaction Steps

A solution of the compound (225 mg, 0.709 mmol) obtained in step 5, WSC (204 mg, 1.06 mmol), HOBt (163 mg, 1.06 mmol), TEA (0.198 mL, 1.42 mmol) and (tetrahydro-2H-pyran-4-yl)methanamine (98.0 mg, 0.851 mmol) in DMF (2.8 mL) was stirred at 100° C. for 1 hr. The reaction solution was cooled, added to water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 1→10% methanol/ethyl acetate) to give the title compound (192 mg, 65%) as a yellow powder.

Provenance & Evidence