Hydrochloric Acid → HCID 86721238, compound

Participants

Reaction Steps

To a solution of the compound (0.380 g, 1.00 mmol) obtained in step 5 in ethanol (4.0 mL) was added 6N aqueous sodium hydroxide solution (0.500 mL, 2.99 mmol) at room temperature, and the mixture was heated under reflux for 30 min. After cooling to room temperature, concentrated hydrochloric acid was added until the mixture became pH 6. The reaction mixture was extracted with dichloromethane. The organic layer was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure to give (2-[1-(difluoromethyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl)acetic acid (0.320 g, 91%) as a yellow powder.

Provenance & Evidence