Hydrochloric Acid → HCID 90184716, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound (95 mg, 0.30 mmol) obtained in step 1 in methanol (3 mL) was added 6N aqueous sodium hydroxide solution (0.05 mL), and the mixture was stirred at 60° C. for 1 hr. To the reaction mixture were added water and 6M hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure to give 5-(4-fluorophenyl)-1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazole-4-carboxamide (60 mg, 0.216 mmol, 73%) as a white powder.

Provenance & Evidence