Lawesson's reagent → HCID 86721241, compound

Participants

Reaction Steps

A solution of the compound (3.59 g, 14.59 mmol) obtained in step 4 and Lawesson's reagent (5.31 g, 13.13 mmol) in THF (60 mL) was stirred at 60° C. for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by NH-silica gel column chromatography (solvent gradient; 2→50% ethyl acetate/hexane) to give 5-bromo-1-tert-butyl-1H-pyrazole-4-carbothioamide (2.8 g, 10.68 mmol, 73%) as a pale-yellow powder.

Provenance & Evidence