Sodium Hydroxide → HCID 86721243, compound

Participants

Reaction Steps

A mixed solution of the compound (2.55 g, 6.85 mmol) obtained in step 6 and 1N aqueous sodium hydroxide solution (10.27 mL, 10.27 mmol) in ethanol (10 mL) and THF (10 ml) was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. 1N Hydrochloric acid was added thereto, and the precipitate was collected by filtration, and washed with diethyl ether and hexane to give 2-(2-(5-bromo-1-tert-butyl-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (2.23 g, 6.48 mmol, 95%) as a white powder.

Provenance & Evidence