Potassium Phosphate, Tribasic → HCID 71496744, compound

Participants

Reaction Steps

A solution of the compound (100 mg, 0.23 mmol) obtained in step 8, 4-methoxyphenylboronic acid (51.6 mg, 0.34 mmol), tripotassium phosphate (96 mg, 0.45 mmol), S-Phos (6.51 mg, 0.02 mmol) and palladium(II) acetate (1.8 mg, 8.02 μmol) in toluene (1.5 mL) was stirred under an argon atmosphere at 90° C. for 18 hr. The reaction mixture was purified by silica gel column chromatography (solvent gradient; 50% ethyl acetate/hexane→5% methanol/ethyl acetate) to give the title compound (55 mg, 0.117 mmol, 52%) as a white powder.

Provenance & Evidence