Lawesson's reagent → HCID 86721245, compound

Participants

Reaction Steps

A solution of the compound (1.45 g, 5.30 mmol) obtained in step 10 and Lawesson's reagent (2.146 g, 5.30 mmol) in THF (25 mL) was stirred at 60° C. for 20 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by NH-silica gel column chromatography (solvent gradient; 2→60% ethyl acetate/hexane) to give 1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carbothioamide (0.81 g, 2.80 mmol, 53%) as a pale-yellow powder.

Provenance & Evidence