Ethyl 4-chloroacetoacetate → HCID 86721247, compound

Participants

Reaction Steps

A solution of the compound (700 mg, 2.42 mmol) obtained in step 11 and ethyl 4-chloroacetoacetate (0.392 mL, 2.90 mmol) in ethanol (5 mL) was stirred at 80° C. for 16 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from diethyl ether and hexane to give ethyl 2-(2-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetate (920 mg, 2.33 mmol, 95%) as a pale-yellow powder.

Provenance & Evidence