Sodium Hydroxide → HCID 86721248, compound

Participants

Reaction Steps

A mixed solution of the compound (920 mg, 2.30 mmol) obtained in step 12 and 1N aqueous sodium hydroxide solution (3.45 mL, 3.45 mmol) in ethanol (10 mL) and THF (10 ml) was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. 1N Hydrochloric acid was added thereto, and the precipitate was collected by filtration to give 2-(2-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (780 mg, 2.10 mmol, 91%) as a white powder.

Provenance & Evidence